A friend who suffers from acne just asked, does CBD work for it...?
Yes it does and because CBD has anti-fungal and anti-bacterial properties as well as "CBD oil triggered an anti-inflammatory reaction in the cells and prevented inflammatory cytokines from activating. Cytokines may trigger acne, so reducing them may help prevent further breakouts."
From the article in Medical News Today:
https://www.medicalnewstoday.com/articles/324689#does-it-work - "A 2014 study explored the effects of CBD on human sebocytes, which are the cells that create sebum. The researchers found that the CBD prevented these cells from creating too much of the oily sebum.
They also revealed that the CBD oil triggered an anti-inflammatory reaction in the cells and prevented inflammatory cytokines from activating. Cytokines may trigger acne, so reducing them may help prevent further breakouts.
A 2016 review of the cannabis plant highlighted its antibacterial and antifungal effects. These effects may help reduce infections from dirt and other pollutants on the skin.
While the initial results from these studies are promising, human trials are still lacking. For doctors to recommend CBD oil or cannabis products as part of an anti-acne skincare routine, studies in humans will need to provide direct evidence."
The published study on the National Institutes of Health site, from the US National Library of Medicine states:
"Administration of CBD to cultured human sebocytes and human skin organ culture inhibited the lipogenic actions of various compounds, including arachidonic acid and a combination of linoleic acid and testosterone, and suppressed sebocyte proliferation via the activation of transient receptor potential vanilloid-4 (TRPV4) ion channels. Activation of TRPV4 interfered with the prolipogenic ERK1/2 MAPK pathway and resulted in the downregulation of nuclear receptor interacting protein-1 (NRIP1), which influences glucose and lipid metabolism, thereby inhibiting sebocyte lipogenesis. CBD also exerted complex antiinflammatory actions that were coupled to A2a adenosine receptor-dependent upregulation of tribbles homolog 3 (TRIB3) and inhibition of the NF-κB signaling. Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris." https://www.ncbi.nlm.nih.gov/pubmed/25061872/
And yes that is somewhat true, "human trials are lacking" but the studies are out there so do your research- and the studies continue to be funded and are under way so keep an eye out as more and more FACTS on CBD continue to be revealed.